The symposium is co-organised by The Ann Conroy Trust, in association with Aesculap Academia.
The Ann Conroy Trust is Registered Charity No: 1165808.
We provide Support, Education and Research for patients living with Chiari Malformation, Syringomyelia and associated conditions.
F29 The mechanical role of oedema in cavity formation.
Venton J, Harris P, Phillips G, Hardwidge C.
Oedema, sometimes referred to as the pre-syrinx state, has been noted prior to cavity formation, both clinically and in experimental syringomyelia. How this might contribute to cavity formation from a mechanical perspective is uncertain.
A computer simulation of a two-dimensional, cross-section of the spinal cord has been developed. The cord was modelled as a poro-elastic material, which allows both the tissue and interstitial fluid to be examined. A region of oedema was modelled as an area of increased fluid content and flow in the posterior white matter.
Mechanical stress in the cord cross-section, potentially an indicator of cord damage, was calculated using the model. The region of oedema was to found to cause increased mechanical stress in that area of the spinal cord, suggesting that damage is more likely to occur.
Further simulations of oedema in the spinal cord would be beneficial to understand how the presence of oedema increases the risk of cavity formation. A better understanding of the relation between oedema position and syrinx risk would be beneficial in determining the likelihood of syrinx formation, or of an existing syrinx worsening.